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Anti -Glucocorticoid Receptor Rabbit pAb




货号:GB11296

规格:100 μl

交货周期:现货

运杂费: 登录后可查看运杂费

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产品属性


反应种属 H,Rat,M
来源宿主 Rabbit
试验方法 IHC、IF 、WB
标记 无标记
类别 一抗

Product Information

 

Description

Glucocorticoid receptor rabbit polyclonal

Protein full name

Glucocorticoid receptor

Synonyms

NR3C1, GCCR, GCR, GCRST, GR, GRL, nuclear receptor subfamily 3 group C member 1, Glucocorticoid Receptor

Immunogen

Recombinant protein corresponding to Mouse Glucocorticoid receptor

Isotype IgG
Purity Affinity purification

Predicted MW.

91KDa

Observed MW.

91KDa

Subcellular location

Cytoplasm,Nucleus,Mitochondrion

Uniprot ID

P04150,P06536,P06537

 

 


 

Applications

 

Applications

WB

IHC,IF

 
Species

Human,Mouse,Rat

Mouse,Rat

 
Dilution

1:500-1:1000

1:1000-1:3000

 
Positive tissue

Hela,kidney,heart

liver,spleen

 

 

 


 

Background

Function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoidresponsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalizedglucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities .

     


 

Images

 

blob.png

Western blot analysis of Glucocorticoid receptor (GB11296) at dilution of 1:1000.

 

Lane 1:Hela cell lysate

Lane 2:HepG2 cell lysate

Lane 3:MCF7 cell lysate

Lane 4:Mouse heart tissue lysate

Lane 5:Mouse kidney tissue lysate

Lane 6:Mouse brain tissue lysate

Lane 7:Rat heart tissue lysate

Lane 8:Rat kidney tissue lysate

 

   
blob.png

Immunohistochemistry analysis of paraffin-embedded rat liver using Glucocorticoid receptor (GB11296) at dilution of 1:3000

 

   
blob.png

Immunohistochemistry analysis of paraffin-embedded rat spleen using Glucocorticoid receptor (GB11296) at dilution of 1:3000

 

   
blob.png

Immunohistochemistry analysis of paraffin-embedded mouse liver using Glucocorticoid receptor (GB11296) at dilution of 1:3000

 

   
blob.png

Immunohistochemistry analysis of paraffin-embedded mouse spleen using Glucocorticoid receptor (GB11296) at dilution of 1:3000

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

 

NOTE: This product is intended for research only.